John H Krystal Selected Research

Substance Withdrawal Syndrome (Withdrawal Symptoms)

4/2007	Antiglutamatergic strategies for ethanol detoxification: comparison with placebo and diazepam.
4/2007	Multidimensionality of the Alcohol Withdrawal Symptom Checklist: a factor analysis of the Alcohol Withdrawal Symptom Checklist and CIWA-Ar.
9/2006	Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment.

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John H Krystal Research Topics

Disease

59	Schizophrenia (Dementia Praecox) 01/2024 - 06/2002
50	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 10/2023 - 05/2008
47	Alcoholism (Alcohol Abuse) 03/2024 - 07/2002
23	Psychotic Disorders (Schizoaffective Disorder) 07/2023 - 04/2002
13	Wounds and Injuries (Trauma) 10/2023 - 09/2011
13	Mental Disorders (Mental Disorder) 06/2023 - 04/2004
12	Treatment-Resistant Depressive Disorder 04/2024 - 03/2003
10	Major Depressive Disorder (Major Depressive Disorders) 03/2024 - 05/2003
10	Mood Disorders (Mood Disorder) 01/2024 - 11/2003
8	Substance-Related Disorders (Drug Abuse) 06/2023 - 05/2004
8	Cognitive Dysfunction 01/2023 - 05/2004
7	Anxiety Disorders (Anxiety Disorder) 06/2023 - 12/2004
7	Bipolar Disorder (Manic Depressive Psychosis) 06/2023 - 04/2006
7	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 12/2012 - 05/2003
6	Panic Disorder (Panic Attack) 11/2019 - 03/2004
5	Hallucinations (Hallucination) 01/2022 - 01/2003
3	Sleepiness 10/2022 - 08/2011
3	Syndrome (Syndromes) 01/2022 - 04/2017
3	Substance Withdrawal Syndrome (Withdrawal Symptoms) 04/2007 - 09/2006
2	Genetic Risk Score 01/2024 - 10/2023
2	Borderline Personality Disorder (Personality Disorders, Borderline) 01/2023 - 11/2005
2	Pain (Aches) 02/2022 - 01/2020
2	Obesity 01/2022 - 01/2021
2	Tobacco Use Disorder (Nicotine Dependence) 10/2018 - 09/2011
2	Treatment-Resistant Schizophrenia 01/2018 - 06/2009
2	Opioid-Related Disorders (Opiate Addiction) 09/2014 - 04/2002
2	Drug Resistant Epilepsy 08/2008 - 03/2002
2	Epilepsy (Aura) 08/2008 - 02/2005
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2008 - 01/2006
1	Inflammation (Inflammations) 10/2023
1	Chronic Disease (Chronic Diseases) 07/2023
1	Autism Spectrum Disorder 06/2023

Drug/Important Bio-Agent (IBA)

46	Ketamine FDA LinkGeneric 04/2024 - 11/2003
31	Glutamic Acid (Glutamate)FDA Link 07/2023 - 07/2003
25	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2022 - 07/2002
23	Antidepressive Agents (Antidepressants)IBA 01/2024 - 03/2007
21	N-Methylaspartate (NMDA)IBA 01/2023 - 07/2003
16	gamma-Aminobutyric Acid (GABA)IBA 01/2021 - 09/2002
15	Antipsychotic Agents (Antipsychotics)IBA 01/2024 - 06/2002
12	Biomarkers (Surrogate Marker)IBA 01/2024 - 10/2005
12	Glutamate Receptors (Glutamate Receptor)IBA 01/2023 - 07/2003
9	Naltrexone (ReVia)FDA LinkGeneric 01/2019 - 03/2004
9	Risperidone (Risperdal Consta)FDA LinkGeneric 12/2017 - 03/2011
8	Ethanol (Ethyl Alcohol)IBA 10/2013 - 07/2003
8	Riluzole FDA LinkGeneric 01/2008 - 05/2003
7	Nicotine FDA Link 01/2014 - 04/2004
6	Serotonin (5 Hydroxytryptamine)IBA 01/2020 - 07/2002
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2011
5	Dopamine (Intropin)FDA LinkGeneric 02/2020 - 09/2005
5	Cycloserine (Seromycin)FDA Link 11/2019 - 02/2010
4	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2023 - 01/2006
4	EnzymesIBA 09/2022 - 12/2004
4	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2018 - 12/2006
4	Excitatory Amino Acid AntagonistsIBA 01/2017 - 10/2004
4	Amino Acids FDA Link 01/2008 - 11/2003
3	GlucocorticoidsIBA 10/2023 - 01/2017
3	Therapeutic UsesIBA 02/2022 - 01/2019
3	BenzodiazepinesIBA 11/2019 - 12/2004
3	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2018 - 05/2008
3	Memantine (Namenda)FDA Link 02/2015 - 04/2006
3	Neurotransmitter Agents (Neurotransmitter)IBA 05/2013 - 11/2003
3	Protons (Proton)IBA 08/2006 - 09/2002
2	RNA (Ribonucleic Acid)IBA 10/2023 - 07/2013
2	1-methyl-1H-imidazole-4-carboxylic acid (3- chloro- 4- fluoro- benzyl)- (3- methyl- 3- aza- bicyclo(3.1.0) hex-6-ylmethyl)amideIBA 01/2023 - 01/2018
2	Cholinergic Agents (Cholinergics)IBA 12/2022 - 12/2006
2	EsketamineIBA 06/2022 - 12/2017
2	CannabinoidsIBA 02/2022 - 01/2011
2	Phosphotransferases (Kinase)IBA 01/2022 - 01/2022
2	saracatinibIBA 01/2022 - 01/2021
2	Hydrocortisone (Cortisol)FDA LinkGeneric 10/2021 - 04/2002
2	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 01/2021 - 05/2004
2	Metabotropic Glutamate 5 ReceptorIBA 11/2020 - 01/2017
2	metabotropic glutamate receptor 2IBA 10/2020 - 08/2010
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2019 - 12/2017
2	Apolipoproteins E (ApoE)IBA 01/2019 - 01/2018
2	ApolipoproteinsIBA 01/2019 - 01/2018
2	Haloperidol (Haldol)FDA LinkGeneric 01/2014 - 06/2009
2	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 12/2011 - 06/2007
2	Clozapine (Clozaril)FDA LinkGeneric 06/2009 - 07/2005
2	Glutamine (L-Glutamine)FDA Link 08/2008 - 02/2005
2	Excitatory Amino Acid AgentsIBA 05/2008 - 07/2003
2	Disulfiram (Antabuse)FDA Link 01/2008 - 03/2004
2	Butyric Acid (Butanoic Acid)IBA 03/2007 - 04/2005
2	GABA-A Receptors (GABA(A) Receptor)IBA 09/2006 - 08/2005
2	NeurosteroidsIBA 08/2006 - 09/2002
2	salicylhydroxamic acid (SHAM)IBA 07/2005 - 01/2003
1	Midazolam (Versed)FDA LinkGeneric 10/2023
1	medrysone FDA Link 10/2023
1	Clofibrate FDA Link 10/2023
1	OrexinsIBA 01/2023
1	mesoglycanIBA 01/2023
1	Corticotropin-Releasing HormoneIBA 01/2023
1	Biological FactorsIBA 01/2023
1	Glycine Plasma Membrane Transport ProteinsIBA 01/2023

Therapy/Procedure

28	Drug Therapy (Chemotherapy) 10/2021 - 09/2003
17	Therapeutics 04/2024 - 09/2005
3	Injections 01/2014 - 03/2011
3	Transcranial Magnetic Stimulation 11/2007 - 01/2003
1	Activities of Daily Living (ADL) 03/2024
1	Cognitive Training 01/2023